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10.4137/CMC.S32667 http://scihub22266oqcxt.onion/10.4137/CMC.S32667 C4790583!4790583 !26997876     free     free     free Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=26997876 &cmd=llinks): Failed to open stream: HTTP request failed! HTTP/1.1 429 Too Many Requests in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 215 Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\26997876 .jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117       Clin+Med+Insights+Cardiol 2016 ; 10 (ä): 37-42 Nephropedia Template TP {{tp|p=26997876 |t=2016. CETP Inhibition: Past Failures and Future Hopes |pdf=|usr=}}{{26997876 }} gab.com Text CETP Inhibition: Past Failures and Future Hopes JO: Clin Med Insights Cardiol http://www.kidney.de/pget.php?&tw=1&pmid=26997876 #FOAvip The atheroprotective role of high-density lipoprotein cholesterol (HDL-C) in cardiovascular disease has been unequivocally established, and epidemiological data have clearly demonstrated a strong inverse relationship between HDL-C levels and the risk of cardiovascular events, which is independent of the low-density lipoprotein cholesterol (LDL-C) levels. Thus, it would be logical to hypothesize that raising HDL-C might potentially lead to a reduction of cardiovascular risk. Cholesteryl ester transfer protein (CETP) promotes the transfer of cholesteryl esters from HDL to very low-density lipoprotein and LDL. Therefore, CETP inhibition raises HDL-C levels and decreases LDL-C levels. The first trials with CETP inhibitors failed to show a reduction in cardiovascular events. However, newer CETP inhibitors with more favorable effects on lipids are presently being tested in clinical trials with the hope that their use may lead to a reduction in cardiovascular risk. This review aims to provide the current evidence regarding CETP inhibition, as well as the clinical and scientific data pertaining to the new CETP inhibitors in development. Twit Text FOAVip CETP Inhibition: Past Failures and Future Hopes ????Clin Med Insights Cardiol http://www.kidney.de/pget.php?&tw=1&pmid=26997876 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=26997876 #FOAvip English Wikipedia <ref>{{Cite pmid|26997876 }}</ref> CETP Inhibition: Past Failures and Future Hopes #MMPMID26997876 Kosmas CE ; DeJesus E ; Rosario D ; Vittorio TJ Clin Med Insights Cardiol 2016[]; 10 (ä): 37-42 PMID26997876 show ga The atheroprotective role of high-density lipoprotein cholesterol (HDL-C) in cardiovascular disease has been unequivocally established, and epidemiological data have clearly demonstrated a strong inverse relationship between HDL-C levels and the risk of cardiovascular events, which is independent of the low-density lipoprotein cholesterol (LDL-C) levels. Thus, it would be logical to hypothesize that raising HDL-C might potentially lead to a reduction of cardiovascular risk. Cholesteryl ester transfer protein (CETP) promotes the transfer of cholesteryl esters from HDL to very low-density lipoprotein and LDL. Therefore, CETP inhibition raises HDL-C levels and decreases LDL-C levels. The first trials with CETP inhibitors failed to show a reduction in cardiovascular events. However, newer CETP inhibitors with more favorable effects on lipids are presently being tested in clinical trials with the hope that their use may lead to a reduction in cardiovascular risk. This review aims to provide the current evidence regarding CETP inhibition, as well as the clinical and scientific data pertaining to the new CETP inhibitors in development. äCETP Inhibition: Past Failures and Future Hopes (epmc).pdf DeepDyve Pubget Overpricing