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10.1097/COH.0000000000000086 http://scihub22266oqcxt.onion/10.1097/COH.0000000000000086 C4211072!4211072 !25010897     free     free     free Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=25010897 &cmd=llinks): Failed to open stream: HTTP request failed! HTTP/1.1 429 Too Many Requests in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 215       Curr+Opin+HIV+AIDS 2014 ; 9 (5 ): 500-5 Nephropedia Template TP {{tp|p=25010897 |t=2014. CD8 T cell persistence in treated HIV infection |pdf=|usr=}}{{25010897 }} gab.com Text CD8 T cell persistence in treated HIV infection JO: Curr Opin HIV AIDS http://www.kidney.de/pget.php?&tw=1&pmid=25010897 #FOAvip PURPOSE OF REVIEW: Many treated HIV-infected persons maintain persistently high circulating CD8 T cell numbers, even after many years of therapy. Recent reports have suggested that persistent CD8 T cell expansion is associated with higher risk of morbid non-AIDS events. Thus, assessing the mechanisms of CD8 T cell expansion and persistence may give insights into a feature of HIV disease that is clinically important. RECENT FINDINGS: Acute HIV infection is associated with activation and expansion of the CD8 T cell compartment. Expanded CD8 T cells persist throughout the disease course, and in contrast to the plasticity that typically characterizes immune responses to most other pathogens, circulating CD8 T cell numbers do not normalize in many patients despite pharmacologic suppression of HIV replication. We suspect that residual inflammation in treated HIV infection contributes to antigen-independent CD8 T cell expansion and persistence as most of these cells are not HIV-reactive. SUMMARY: Circulating CD8 T cell numbers remain abnormally elevated in many treated HIV-infected patients and this elevation is associated with adverse clinical events. Future studies will be needed to assess the mechanisms of CD8 T cell expansion and to define the role of CD8 lymphocytosis in the clinical course of treated HIV disease. Twit Text FOAVip CD8 T cell persistence in treated HIV infection ????Curr Opin HIV AIDS http://www.kidney.de/pget.php?&tw=1&pmid=25010897 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=25010897 #FOAvip English Wikipedia <ref>{{Cite pmid|25010897 }}</ref> CD8 T cell persistence in treated HIV infection #MMPMID25010897 Mudd JC ; Lederman MM Curr Opin HIV AIDS 2014[Sep]; 9 (5 ): 500-5 PMID25010897 show ga PURPOSE OF REVIEW: Many treated HIV-infected persons maintain persistently high circulating CD8 T cell numbers, even after many years of therapy. Recent reports have suggested that persistent CD8 T cell expansion is associated with higher risk of morbid non-AIDS events. Thus, assessing the mechanisms of CD8 T cell expansion and persistence may give insights into a feature of HIV disease that is clinically important. RECENT FINDINGS: Acute HIV infection is associated with activation and expansion of the CD8 T cell compartment. Expanded CD8 T cells persist throughout the disease course, and in contrast to the plasticity that typically characterizes immune responses to most other pathogens, circulating CD8 T cell numbers do not normalize in many patients despite pharmacologic suppression of HIV replication. We suspect that residual inflammation in treated HIV infection contributes to antigen-independent CD8 T cell expansion and persistence as most of these cells are not HIV-reactive. SUMMARY: Circulating CD8 T cell numbers remain abnormally elevated in many treated HIV-infected patients and this elevation is associated with adverse clinical events. Future studies will be needed to assess the mechanisms of CD8 T cell expansion and to define the role of CD8 lymphocytosis in the clinical course of treated HIV disease. |*CD8-Positive T-Lymphocytes/immunology/physiology [MESH] |*HIV Infections/immunology/mortality/physiopathology/virology [MESH] |HIV-1/*immunology [MESH]CD8 T cell persistence in treated HIV infection (epmc).pdf DeepDyve Pubget Overpricing