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10.1073/pnas.1612195114 http://scihub22266oqcxt.onion/10.1073/pnas.1612195114 C5255621!5255621 !28031488     free     free     free Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\28031488 .jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117       Proc+Natl+Acad+Sci+U+S+A 2017 ; 114 (3 ): 562-567 Nephropedia Template TP {{tp|p=28031488 |t=2017. CD74 is a novel transcription regulator |pdf=|usr=}}{{28031488 }} gab.com Text CD74 is a novel transcription regulator JO: Proc Natl Acad Sci U S A http://www.kidney.de/pget.php?&tw=1&pmid=28031488 #FOAvip CD74 is a cell-surface receptor for the cytokine macrophage migration inhibitory factor. Macrophage migration inhibitory factor binding to CD74 induces its intramembrane cleavage and the release of its cytosolic intracellular domain (CD74-ICD), which regulates cell survival. In the present study, we characterized the transcriptional activity of CD74-ICD in chronic lymphocytic B cells. We show that following CD74 activation, CD74-ICD interacts with the transcription factors RUNX (Runt related transcription factor) and NF-?B and binds to proximal and distal regulatory sites enriched for genes involved in apoptosis, immune response, and cell migration. This process leads to regulation of expression of these genes. Our results suggest that identifying targets of CD74 will help in understanding of essential pathways regulating B-cell survival in health and disease. Twit Text FOAVip CD74 is a novel transcription regulator ????Proc Natl Acad Sci U S A http://www.kidney.de/pget.php?&tw=1&pmid=28031488 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=28031488 #FOAvip English Wikipedia <ref>{{Cite pmid|28031488 }}</ref> CD74 is a novel transcription regulator #MMPMID28031488 Gil-Yarom N ; Radomir L ; Sever L ; Kramer MP ; Lewinsky H ; Bornstein C ; Blecher-Gonen R ; Barnett-Itzhaki Z ; Mirkin V ; Friedlander G ; Shvidel L ; Herishanu Y ; Lolis EJ ; Becker-Herman S ; Amit I ; Shachar I Proc Natl Acad Sci U S A 2017[Jan]; 114 (3 ): 562-567 PMID28031488 show ga CD74 is a cell-surface receptor for the cytokine macrophage migration inhibitory factor. Macrophage migration inhibitory factor binding to CD74 induces its intramembrane cleavage and the release of its cytosolic intracellular domain (CD74-ICD), which regulates cell survival. In the present study, we characterized the transcriptional activity of CD74-ICD in chronic lymphocytic B cells. We show that following CD74 activation, CD74-ICD interacts with the transcription factors RUNX (Runt related transcription factor) and NF-?B and binds to proximal and distal regulatory sites enriched for genes involved in apoptosis, immune response, and cell migration. This process leads to regulation of expression of these genes. Our results suggest that identifying targets of CD74 will help in understanding of essential pathways regulating B-cell survival in health and disease. äCD74 is a novel transcription regulator (epmc).pdf DeepDyve Pubget Overpricing