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10.1007/s11302-017-9596-x http://scihub22266oqcxt.onion/10.1007/s11302-017-9596-x C5940625!5940625 !29332180     free     free     free Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\29332180 .jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117       Purinergic+Signal 2018 ; 14 (2 ): 109-120 Nephropedia Template TP {{tp|p=29332180 |t=2018. CD39-adenosinergic axis in renal pathophysiology and therapeutics |pdf=|usr=}}{{29332180 }} gab.com Text CD39-adenosinergic axis in renal pathophysiology and therapeutics JO: Purinergic Signal http://www.kidney.de/pget.php?&tw=1&pmid=29332180 #FOAvip Extracellular ATP interacts with purinergic type 2 (P2) receptors and elicits many crucial biological functions. Extracellular ATP is sequentially hydrolyzed to ADP and AMP by the actions of defined nucleotidases, such as CD39, and AMP is converted to adenosine, largely by CD73, an ecto-5'-nucleotidase. Extracellular adenosine interacts with P1 receptors and often opposes the effects of P2 receptor activation. The balance between extracellular ATP and adenosine in the blood and extracellular fluid is regulated chiefly by the activities of CD39 and CD73, which constitute the CD39-adenosinergic axis. In recent years, several studies have shown this axis to play critical roles in transport of water/sodium, tubuloglomerular feedback, renin secretion, ischemia reperfusion injury, renal fibrosis, hypertension, diabetic nephropathy, transplantation, inflammation, and macrophage transformation. Important developments include global and targeted gene knockout and/or transgenic mouse models of CD39 or CD73, biological or small molecule inhibitors, and soluble engineered ectonucleotidases to directly impact the CD39-adenosinergic axis. This review presents a comprehensive picture of the multiple roles of CD39-adenosinergic axis in renal physiology, pathophysiology, and therapeutics. Scientific advances and greater understanding of the role of this axis in the kidney, in both health and illness, will direct development of innovative therapies for renal diseases. Twit Text FOAVip CD39-adenosinergic axis in renal pathophysiology and therapeutics ????Purinergic Signal http://www.kidney.de/pget.php?&tw=1&pmid=29332180 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=29332180 #FOAvip English Wikipedia <ref>{{Cite pmid|29332180 }}</ref> CD39-adenosinergic axis in renal pathophysiology and therapeutics #MMPMID29332180 Kishore BK ; Robson SC ; Dwyer KM Purinergic Signal 2018[Jun]; 14 (2 ): 109-120 PMID29332180 show ga Extracellular ATP interacts with purinergic type 2 (P2) receptors and elicits many crucial biological functions. Extracellular ATP is sequentially hydrolyzed to ADP and AMP by the actions of defined nucleotidases, such as CD39, and AMP is converted to adenosine, largely by CD73, an ecto-5'-nucleotidase. Extracellular adenosine interacts with P1 receptors and often opposes the effects of P2 receptor activation. The balance between extracellular ATP and adenosine in the blood and extracellular fluid is regulated chiefly by the activities of CD39 and CD73, which constitute the CD39-adenosinergic axis. In recent years, several studies have shown this axis to play critical roles in transport of water/sodium, tubuloglomerular feedback, renin secretion, ischemia reperfusion injury, renal fibrosis, hypertension, diabetic nephropathy, transplantation, inflammation, and macrophage transformation. Important developments include global and targeted gene knockout and/or transgenic mouse models of CD39 or CD73, biological or small molecule inhibitors, and soluble engineered ectonucleotidases to directly impact the CD39-adenosinergic axis. This review presents a comprehensive picture of the multiple roles of CD39-adenosinergic axis in renal physiology, pathophysiology, and therapeutics. Scientific advances and greater understanding of the role of this axis in the kidney, in both health and illness, will direct development of innovative therapies for renal diseases. |Adenosine Triphosphate/*metabolism [MESH] |Adenosine/*metabolism [MESH] |Animals [MESH] |Apyrase/*physiology [MESH] |Humans [MESH]CD39-adenosinergic axis in renal pathophysiology and therapeutics (epmc).pdf DeepDyve Pubget Overpricing