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10.1016/j.molmed.2017.03.002 http://scihub22266oqcxt.onion/10.1016/j.molmed.2017.03.002 C5423782!5423782 !28416139     free     free     free Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\28416139 .jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117       Trends+Mol+Med 2017 ; 23 (5 ): 430-450 Nephropedia Template TP {{tp|p=28416139 |t=2017. CARs: Synthetic Immunoreceptors for Cancer Therapy and Beyond |pdf=|usr=}}{{28416139 }} gab.com Text CARs: Synthetic Immunoreceptors for Cancer Therapy and Beyond JO: Trends Mol Med http://www.kidney.de/pget.php?&tw=1&pmid=28416139 #FOAvip Chimeric antigen receptors (CARs) are versatile synthetic receptors that provide T cells with engineered specificity. Clinical success in treating B-cell malignancies has demonstrated the therapeutic potential of CAR-T cells against cancer, and efforts are underway to expand the use of engineered T cells to the treatment of diverse medical conditions, including infections and autoimmune diseases. Here, we review current understanding of the molecular properties of CARs, how this knowledge informs the rational design and characterization of novel receptors, the successes and shortcomings of CAR-T cells in the clinic, and emerging solutions for the continued improvement of CAR-T cell therapy. Twit Text FOAVip CARs: Synthetic Immunoreceptors for Cancer Therapy and Beyond ????Trends Mol Med http://www.kidney.de/pget.php?&tw=1&pmid=28416139 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=28416139 #FOAvip English Wikipedia <ref>{{Cite pmid|28416139 }}</ref> CARs: Synthetic Immunoreceptors for Cancer Therapy and Beyond #MMPMID28416139 Chang ZL ; Chen YY Trends Mol Med 2017[May]; 23 (5 ): 430-450 PMID28416139 show ga Chimeric antigen receptors (CARs) are versatile synthetic receptors that provide T cells with engineered specificity. Clinical success in treating B-cell malignancies has demonstrated the therapeutic potential of CAR-T cells against cancer, and efforts are underway to expand the use of engineered T cells to the treatment of diverse medical conditions, including infections and autoimmune diseases. Here, we review current understanding of the molecular properties of CARs, how this knowledge informs the rational design and characterization of novel receptors, the successes and shortcomings of CAR-T cells in the clinic, and emerging solutions for the continued improvement of CAR-T cell therapy. |B-Lymphocytes/immunology/metabolism [MESH] |Humans [MESH] |Immunotherapy, Adoptive/methods [MESH] |Neoplasms/immunology/metabolism [MESH] |Receptors, Antigen, T-Cell/immunology/*metabolism [MESH] |Synthetic Biology [MESH]CARs: Synthetic Immunoreceptors for Cancer Therapy and Beyond (epmc).pdf DeepDyve Pubget Overpricing