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.jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117 J+Surg+Oncol
2017 ; 116
(1
): 63-74
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CAR T-cell therapy for pancreatic cancer
#MMPMID28346697
DeSelm CJ
; Tano ZE
; Varghese AM
; Adusumilli PS
J Surg Oncol
2017[Jul]; 116
(1
): 63-74
PMID28346697
show ga
Chimeric antigen receptor (CAR) T-cell therapy utilizes genetic engineering to
redirect a patient's own T cells to target cancer cells. The remarkable results
in hematological malignancies prompted investigating this approach in solid
tumors such as pancreatic cancer. The complex tumor microenvironment, stromal
hindrance in limiting immune response, and expression of checkpoint blockade on T
cells pose hurdles. Herein, we summarize the opportunities, challenges, and state
of knowledge in targeting pancreatic cancer with CAR T-cell therapy.