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2014 ; 24
(10
): 1248-60
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CA1 subfield contributions to memory integration and inference
#MMPMID24888442
Schlichting ML
; Zeithamova D
; Preston AR
Hippocampus
2014[Oct]; 24
(10
): 1248-60
PMID24888442
show ga
The ability to combine information acquired at different times to make novel
inferences is a powerful function of episodic memory. One perspective suggests
that by retrieving related knowledge during new experiences, existing memories
can be linked to the new, overlapping information as it is encoded. The resulting
memory traces would thus incorporate content across event boundaries,
representing important relationships among items encountered during separate
experiences. While prior work suggests that the hippocampus is involved in
linking memories experienced at different times, the involvement of specific
subfields in this process remains unknown. Using both univariate and multivariate
analyses of high-resolution functional magnetic resonance imaging (fMRI) data, we
localized this specialized encoding mechanism to human CA1 . Specifically, right
CA1 responses during encoding of events that overlapped with prior experience
predicted subsequent success on a test requiring inferences about the
relationships among events. Furthermore, we employed neural pattern similarity
analysis to show that patterns of activation evoked during overlapping event
encoding were later reinstated in CA1 during successful inference. The
reinstatement of CA1 patterns during inference was specific to those trials that
were performed quickly and accurately, consistent with the notion that linking
memories during learning facilitates novel judgments. These analyses provide
converging evidence that CA1 plays a unique role in encoding overlapping events
and highlight the dynamic interactions between hippocampal-mediated encoding and
retrieval processes. More broadly, our data reflect the adaptive nature of
episodic memories, in which representations are derived across events in
anticipation of future judgments.
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