Use my Search Websuite to scan PubMed, PMCentral, Journal Hosts and Journal Archives, FullText. Kick-your-searchterm to multiple Engines kick-your-query now !>

A dictionary by aggregated review articles of nephrology, medicine and the life sciences Your one-stop-run pathway from word to the immediate pdf of peer-reviewed on-topic knowledge.

10.1038/srep14999 http://scihub22266oqcxt.onion/10.1038/srep14999 C4602310!4602310 !26459930     free     free     free Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=26459930 &cmd=llinks): Failed to open stream: HTTP request failed! HTTP/1.1 429 Too Many Requests in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 215 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\26459930 .jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117       Sci+Rep 2015 ; 5 (ä): 14999 Nephropedia Template TP {{tp|p=26459930 |t=2015. Bursts of Bipolar Microsecond Pulses Inhibit Tumor Growth |pdf=|usr=}}{{26459930 }} gab.com Text Bursts of Bipolar Microsecond Pulses Inhibit Tumor Growth JO: Sci Rep http://www.kidney.de/pget.php?&tw=1&pmid=26459930 #FOAvip Irreversible electroporation (IRE) is an emerging focal therapy which is demonstrating utility in the treatment of unresectable tumors where thermal ablation techniques are contraindicated. IRE uses ultra-short duration, high-intensity monopolar pulsed electric fields to permanently disrupt cell membranes within a well-defined volume. Though preliminary clinical results for IRE are promising, implementing IRE can be challenging due to the heterogeneous nature of tumor tissue and the unintended induction of muscle contractions. High-frequency IRE (H-FIRE), a new treatment modality which replaces the monopolar IRE pulses with a burst of bipolar pulses, has the potential to resolve these clinical challenges. We explored the pulse-duration space between 250 ns and 100 ?s and determined the lethal electric field intensity for specific H-FIRE protocols using a 3D tumor mimic. Murine tumors were exposed to 120 bursts, each energized for 100 ?s, containing individual pulses 1, 2, or 5 ?s in duration. Tumor growth was significantly inhibited and all protocols were able to achieve complete regressions. The H-FIRE protocol substantially reduces muscle contractions and the therapy can be delivered without the need for a neuromuscular blockade. This work shows the potential for H-FIRE to be used as a focal therapy and merits its investigation in larger pre-clinical models. Twit Text FOAVip Bursts of Bipolar Microsecond Pulses Inhibit Tumor Growth ????Sci Rep http://www.kidney.de/pget.php?&tw=1&pmid=26459930 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=26459930 #FOAvip English Wikipedia <ref>{{Cite pmid|26459930 }}</ref> Bursts of Bipolar Microsecond Pulses Inhibit Tumor Growth #MMPMID26459930 Sano MB ; Arena CB ; Bittleman KR ; DeWitt MR ; Cho HJ ; Szot CS ; Saur D ; Cissell JM ; Robertson J ; Lee YW ; Davalos RV Sci Rep 2015[Oct]; 5 (ä): 14999 PMID26459930 show ga Irreversible electroporation (IRE) is an emerging focal therapy which is demonstrating utility in the treatment of unresectable tumors where thermal ablation techniques are contraindicated. IRE uses ultra-short duration, high-intensity monopolar pulsed electric fields to permanently disrupt cell membranes within a well-defined volume. Though preliminary clinical results for IRE are promising, implementing IRE can be challenging due to the heterogeneous nature of tumor tissue and the unintended induction of muscle contractions. High-frequency IRE (H-FIRE), a new treatment modality which replaces the monopolar IRE pulses with a burst of bipolar pulses, has the potential to resolve these clinical challenges. We explored the pulse-duration space between 250 ns and 100 ?s and determined the lethal electric field intensity for specific H-FIRE protocols using a 3D tumor mimic. Murine tumors were exposed to 120 bursts, each energized for 100 ?s, containing individual pulses 1, 2, or 5 ?s in duration. Tumor growth was significantly inhibited and all protocols were able to achieve complete regressions. The H-FIRE protocol substantially reduces muscle contractions and the therapy can be delivered without the need for a neuromuscular blockade. This work shows the potential for H-FIRE to be used as a focal therapy and merits its investigation in larger pre-clinical models. |Animals [MESH] |Cell Line, Tumor [MESH] |Disease Models, Animal [MESH] |Electroporation/*methods [MESH] |Male [MESH] |Mice [MESH] |Neoplasms/*pathology/*therapy [MESH] |Tumor Burden [MESH]Bursts of Bipolar Microsecond Pulses Inhibit Tumor Growth (epmc).pdf DeepDyve Pubget Overpricing