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2012 ; 25
(5
): 555-63
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Burden of disease from cryptosporidiosis
#MMPMID22907279
Shirley DA
; Moonah SN
; Kotloff KL
Curr Opin Infect Dis
2012[Oct]; 25
(5
): 555-63
PMID22907279
show ga
PURPOSE OF REVIEW: The global significance of cryptosporidiosis is widespread and
far-reaching. In this review, we present recent data about strain diversity and
the burden of disease, along with developments in therapeutic and preventive
strategies. RECENT FINDINGS: Cryptosporidium is an emerging pathogen that
disproportionately affects children in developing countries and immunocompromised
individuals. Without a diagnostic tool amenable for use in developing countries,
the burden of infection and its relationship to growth faltering, malnutrition,
and diarrheal mortality remain underappreciated. Disease incidence is also
increasing in industrialized countries largely as a result of outbreaks in
recreational water facilities. Advances in molecular methods, including subtyping
analysis, have yielded new insights into the epidemiology of cryptosporidiosis.
However, without practical point-of-care diagnostics, an effective treatment for
immunocompromised patients, and a promising vaccine candidate, the ability to
reduce the burden of disease in the near future is limited. This is compounded by
inadequate coverage with antiretroviral therapy in developing countries, the only
current means of managing HIV-infected patients with cryptosporidiosis. SUMMARY:
Cryptosporidiosis is one of the most important diarrheal pathogens affecting
people worldwide. Effective methods to control and treat cryptosporidiosis among
high-risk groups present an ongoing problem in need of attention.
|*Cost of Illness
[MESH]
|*Cryptosporidiosis/diagnosis/drug therapy/epidemiology/prevention & control
[MESH]
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