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2016 ; 38
(10
): 997-1002
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Building on the Ccr4-Not architecture
#MMPMID27545501
Villanyi Z
; Collart MA
Bioessays
2016[Oct]; 38
(10
): 997-1002
PMID27545501
show ga
In a recent issue of Nature Communications Ukleja and co-workers reported a
cryo-EM 3D reconstruction of the Ccr4-Not complex from Schizosaccharomyces pombe
with an immunolocalization of the different subunits. The newly gained
architectural knowledge provides cues to apprehend the functional diversity of
this major eukaryotic regulator. Indeed, in the cytoplasm alone, Ccr4-Not
regulates translational repression, decapping and deadenylation, and the Not
module additionally plays a positive role in translation. The spatial
distribution of the subunits within the structure is compatible with a model
proposing that the Ccr4-Not complex interacts with the 5' and 3' ends of target
mRNAs, allowing different functional modules of the complex to act at different
stages of the translation process, possibly within a circular constellation of
the mRNA. This work opens new avenues, and reveals important gaps in our
understanding regarding structure and mode of function of the Ccr4-Not complex
that need to be addressed in the future.
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