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2015 ; 15
(6
): 361-70
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Building better monoclonal antibody-based therapeutics
#MMPMID25998715
Weiner GJ
Nat Rev Cancer
2015[Jun]; 15
(6
): 361-70
PMID25998715
show ga
For 20 years, monoclonal antibodies (mAbs) have been a standard component of
cancer therapy, but there is still much room for improvement. Efforts continue to
build better cancer therapeutics based on mAbs. Anticancer mAbs function through
various mechanisms, including directly targeting the malignant cells, modifying
the host response, delivering cytotoxic moieties and retargeting cellular
immunity towards the malignant cells. Characteristics of mAbs that affect their
efficacy include antigen specificity, overall structure, affinity for the target
antigen and how a mAb component is incorporated into a construct that can trigger
target cell death. This Review discusses the various approaches to using
mAb-based therapeutics to treat cancer and the strategies used to take advantage
of the unique potential of each approach, and provides examples of current
mAb-based treatments.