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2016 ; 9
(3
): 1507
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Brugada Syndrome:Risk Stratification And Management
#MMPMID28496938
Aizawa Y
J Atr Fibrillation
2016[Oct]; 9
(3
): 1507
PMID28496938
show ga
The Brugada syndrome (BrS) is an arrhythmogenic disease associated with an
increased risk of ventricular fibrillation and sudden cardiac death. The risk
stratification and management of BrS patients, particularly of asymptomatic ones,
still remains challenging. A previous history of aborted sudden cardiac death or
arrhythmic syncope in the presence of spontaneous type 1 ECG pattern of BrS
phenotype appear to be the most reliable predictors of future arrhythmic events.
Several other ECG parameters have been proposed for risk stratification. Among
these ECG markers, QRS-fragmentation appears very promising. Although the value
of electrophysiological study still remains controversial, it appears to add
important information on risk stratification, particularly when incorporated in
multiparametric scores in combination with other known risk factors. The present
review article provides an update on the pathophysiology, risk stratification and
management of patients with BrS.