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2015 ; 2015
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Bronchitis (acute)
#MMPMID26186368
Wark P
BMJ Clin Evid
2015[Jul]; 2015
(ä): ä PMID26186368
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INTRODUCTION: Acute bronchitis affects more than 40 in 1000 adults per year in
the UK. The causes are usually considered to be infective, but only around half
of people have identifiable pathogens. The role of smoking or of environmental
tobacco smoke inhalation in predisposing to acute bronchitis is unclear. One
third of people may have longer-term symptoms or recurrence. METHODS AND
OUTCOMES: We conducted a systematic review, aiming to answer the following
clinical question: What are the effects of treatments for acute bronchitis in
people without chronic respiratory disease? We searched: Medline, Embase, The
Cochrane Library, and other important databases up to May 2015 (Clinical Evidence
overviews are updated periodically; please check our website for the most
up-to-date version of this overview). RESULTS: At this update, searching of
electronic databases retrieved 420 studies. After deduplication and removal of
conference abstracts, 306 records were screened for inclusion in the overview.
Appraisal of titles and abstracts led to the exclusion of 245 studies and the
further review of 61 full publications. Of the 61 full articles evaluated, three
updated systematic reviews and three RCTs were added at this update. We performed
a GRADE evaluation for 12 PICO combinations. CONCLUSIONS: In this systematic
review we categorised the efficacy for six intervention-comparison combinations,
based on information about the effectiveness and safety of the following
interventions: antibiotics, antihistamines, antitussives, beta2 agonists
(inhaled), and expectorants/mucolytics.
|Acute Disease
[MESH]
|Administration, Inhalation
[MESH]
|Adrenergic beta-2 Receptor Agonists/*therapeutic use
[MESH]