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2017 ; 4
(11
): 384-386
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Breaking the bad: Bacillus blocks fungal virulence factors
#MMPMID29167801
Mayer FL
; Kronstad JW
Microb Cell
2017[Oct]; 4
(11
): 384-386
PMID29167801
show ga
Fungal pathogens rely on the production of specific virulence factors during
infection. Inhibiting such factors generally results in reduced fungal
pathogenicity. Most studies in the past have focused on understanding the
molecular mechanisms of fungal virulence factor expression during mono-culture,
or during interaction with the host. However, a potentially important, second
type of interaction has been less well studied thus far - the interplay of fungal
pathogens of humans with other microbes found in their natural habitat.
Specifically, whether environmental bacteria may impact fungal virulence factor
production is largely unknown. In our recent work, we have identified the soil
bacterium, Bacillus safensis, as a potent inhibitor of virulence factor
production by two major fungal pathogens of humans, Cryptococcus neoformans, and
Candida albicans. We determined that the anti-virulence factor mechanism is, at
least in part, based on production of bacterial chitinases that target and
destabilize the fungal cell surface. These findings describe a cross-kingdom
interaction between an environmental bacterium and pathogenic fungi, and
highlight the fungal cell wall as an attractive antifungal drug target.
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