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10.1186/gb-2013-14-8-r87 http://scihub22266oqcxt.onion/10.1186/gb-2013-14-8-r87 C4054677!4054677 !23972288     free     free     free Deprecated: Implicit conversion from float 227.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 227.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 227.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\23972288 .jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117       Genome+Biol 2013 ; 14 (8 ): R87 Nephropedia Template TP {{tp|p=23972288 |t=2013. BreakTrans: uncovering the genomic architecture of gene fusions |pdf=|usr=}}{{23972288 }} gab.com Text BreakTrans: uncovering the genomic architecture of gene fusions JO: Genome Biol http://www.kidney.de/pget.php?&tw=1&pmid=23972288 #FOAvip Producing gene fusions through genomic structural rearrangements is a major mechanism for tumor evolution. Therefore, accurately detecting gene fusions and the originating rearrangements is of great importance for personalized cancer diagnosis and targeted therapy. We present a tool, BreakTrans, that systematically maps predicted gene fusions to structural rearrangements. Thus, BreakTrans not only validates both types of predictions, but also provides mechanistic interpretations. BreakTrans effectively validates known fusions and discovers novel events in a breast cancer cell line. Applying BreakTrans to 43 breast cancer samples in The Cancer Genome Atlas identifies 90 genomically validated gene fusions. BreakTrans is available at http://bioinformatics.mdanderson.org/main/BreakTrans. Twit Text FOAVip BreakTrans: uncovering the genomic architecture of gene fusions ????Genome Biol http://www.kidney.de/pget.php?&tw=1&pmid=23972288 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=23972288 #FOAvip English Wikipedia <ref>{{Cite pmid|23972288 }}</ref> BreakTrans: uncovering the genomic architecture of gene fusions #MMPMID23972288 Chen K ; Navin NE ; Wang Y ; Schmidt HK ; Wallis JW ; Niu B ; Fan X ; Zhao H ; McLellan MD ; Hoadley KA ; Mardis ER ; Ley TJ ; Perou CM ; Wilson RK ; Ding L Genome Biol 2013[Aug]; 14 (8 ): R87 PMID23972288 show ga Producing gene fusions through genomic structural rearrangements is a major mechanism for tumor evolution. Therefore, accurately detecting gene fusions and the originating rearrangements is of great importance for personalized cancer diagnosis and targeted therapy. We present a tool, BreakTrans, that systematically maps predicted gene fusions to structural rearrangements. Thus, BreakTrans not only validates both types of predictions, but also provides mechanistic interpretations. BreakTrans effectively validates known fusions and discovers novel events in a breast cancer cell line. Applying BreakTrans to 43 breast cancer samples in The Cancer Genome Atlas identifies 90 genomically validated gene fusions. BreakTrans is available at http://bioinformatics.mdanderson.org/main/BreakTrans. |*Chromosome Breakpoints [MESH] |*Oncogene Fusion [MESH] |*Software [MESH] |Atlases as Topic [MESH] |Breast Neoplasms/*genetics [MESH] |Cell Line, Tumor [MESH] |Female [MESH] |Gene Dosage [MESH] |Genome, Human [MESH] |Humans [MESH] |Molecular Sequence Annotation [MESH] |Oncogene Proteins, Fusion/*genetics [MESH]BreakTrans: uncovering the genomic architecture of gene fusions (epmc).pdf DeepDyve Pubget Overpricing