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10.1093/brain/awv250

http://scihub22266oqcxt.onion/10.1093/brain/awv250
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C4731416!4731416!26377633
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suck abstract from ncbi


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pmid26377633      Brain 2015 ; 138 (11): 3206-20
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  • Brain endothelial dysfunction in cerebral adrenoleukodystrophy #MMPMID26377633
  • Musolino PL; Gong Y; Snyder JMT; Jimenez S; Lok J; Lo EH; Moser AB; Grabowski EF; Frosch MP; Eichler FS
  • Brain 2015[Nov]; 138 (11): 3206-20 PMID26377633show ga
  • See Aubourg (doi:10.1093/awv271) for a scientific commentary on this article.Cerebral adrenoleukodystrophy is a neuroinflammatory demyelinating disease caused by mutations in ABCD1. Musolino et al. report that the progressive demyelination coincides with blood-brain barrier disruption and endothelial changes. Silencing endothelial ABCD1 in vitro upregulates expression of adhesion molecules and downregulates expression of tight-junction proteins and c-MYC, promoting monocyte transmigration.
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