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2016 ; 8
(10
): ä Nephropedia Template TP
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Botulinum Toxin A for Controlling Obesity
#MMPMID27681739
Pero R
; Coretti L
; Lembo F
Toxins (Basel)
2016[Sep]; 8
(10
): ä PMID27681739
show ga
Rapid growth of the overweight population and the number of obese individuals in
recent decades suggests that current strategies based on diet, exercise, and
pharmacological knowledge are not sufficient to address this epidemic. Obesity is
the result of a high caloric intake and energy storage, not counterbalanced by an
equally important energy expense. Botulinum toxin type A (BoNT-A) use is rapidly
expanding to include treatment of a variety of ophthalmological,
gastrointestinal, urological, orthopedic, dermatological, secretory, painful, and
cosmetic disorders. Many studies evaluating the effect of BoNT-A in gastric
antrum e/o fundus for the treatment of obesity have been published. This
treatment modality was based on the observation that gastric injection of BoNT-A
in laparatomized rats induced a significant reduction of food intake and body
weight. These studies have been published yielding debated results. Differences
in the selection of patients, the doses of BoNT-A, the method of administration
of the toxin, and the instruments of evaluation of some parameters among these
studies may be the cause. In this review, it will study the state-of-the-art use
of BoNT-A in obesity basic science models and review the clinical evidence on the
therapeutic applications of BoNT-A for obesity.
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