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2016 ; 4
(ä): 16028
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Bone-cartilage crosstalk: a conversation for understanding osteoarthritis
#MMPMID27672480
Findlay DM
; Kuliwaba JS
Bone Res
2016[]; 4
(ä): 16028
PMID27672480
show ga
Although cartilage degradation is the characteristic feature of osteoarthritis
(OA), it is now recognized that the whole joint is involved in the progression of
OA. In particular, the interaction (crosstalk) between cartilage and subchondral
bone is thought to be a central feature of this process. The interface between
articular cartilage and bone of articulating long bones is a unique zone, which
comprises articular cartilage, below which is the calcified cartilage sitting on
and intercalated into the subchondral bone plate. Below the subchondral plate is
the trabecular bone at the end of the respective long bones. In OA, there are
well-described progressive destructive changes in the articular cartilage, which
parallel characteristic changes in the underlying bone. This review examines the
evidence that biochemical and biomechanical signaling between these tissue
compartments is important in OA disease progression and asks whether such
signaling might provide possibilities for therapeutic intervention to halt or
slow disease development.