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2015 ; 80
(ä): 14-18
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Bone development
#MMPMID26453494
Berendsen AD
; Olsen BR
Bone
2015[Nov]; 80
(ä): 14-18
PMID26453494
show ga
The development of the vertebrate skeleton reflects its evolutionary history.
Cartilage formation came before biomineralization and a head skeleton evolved
before the formation of axial and appendicular skeletal structures. This review
describes the processes that result in endochondral and intramembranous
ossification, the important roles of growth and transcription factors, and the
consequences of mutations in some of the genes involved. Following a summary of
the origin of cartilage, muscle, and tendon cell lineages in the axial skeleton,
we discuss the role of muscle forces in the formation of skeletal architecture
and assembly of musculoskeletal functional units. Finally, ontogenetic patterning
of bones in response to mechanical loading is reviewed.This article is part of a
Special Issue entitled "Muscle Bone Interactions".