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2015 ; 24
(4
): 143-52
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Bone age: assessment methods and clinical applications
#MMPMID26568655
Satoh M
Clin Pediatr Endocrinol
2015[Oct]; 24
(4
): 143-52
PMID26568655
show ga
The main bone age assessment methods are the Greulich-Pyle and Tanner-Whitehouse
2 methods, both of which involve left hand and wrist radiographs. Several other
bone age assessment methods have been developed, including ultrasonographic,
computerized, and magnetic resonance (MR) imaging methods. The ultrasonographic
method appears unreliable in children with delayed and advanced bone age. MR
imaging is noninvasive; however, bone age assessment using MR imaging is
relatively new, and further examinations are needed. An automated method for
determining bone age, named BoneXpert, has been validated for Caucasian children
with growth disorders and children of various ethnic groups. Sex hormones are
necessary for bone growth and maturation in children with a bone age
corresponding to normal pubertal age, and estrogen is essential for growth plate
closure. Bone age is an effective indicator for diagnosing and treating various
diseases. A new method for adult height prediction based on bone age has been
developed using BoneXpert, in addition to the commonly used Bayley-Pinneau and
Tanner-Whitehouse mark II methods. Furthermore, bone age may become a predictor
for the timing of peak height velocity and menarche.
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