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.jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117 Curr+Mol+Biol+Rep
2015 ; 1
(3
): 132-140
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Bone Tissue Engineering
#MMPMID26618105
Black CR
; Goriainov V
; Gibbs D
; Kanczler J
; Tare RS
; Oreffo RO
Curr Mol Biol Rep
2015[]; 1
(3
): 132-140
PMID26618105
show ga
Medical advances have led to a welcome increase in life expectancy. However,
accompanying longevity introduces new challenges: increases in age-related
diseases and associated reductions in quality of life. The loss of skeletal
tissue that can accompany trauma, injury, disease or advancing years can result
in significant morbidity and significant socio-economic cost and emphasise the
need for new, more reliable skeletal regeneration strategies. To address the
unmet need for bone augmentation, tissue engineering and regenerative medicine
have come to the fore in recent years with new approaches for de novo skeletal
tissue formation. Typically, these approaches seek to harness stem cells,
innovative scaffolds and biological factors that promise enhanced and more
reliable bone formation strategies to improve the quality of life for many. This
review provides an overview of recent developments in bone tissue engineering
focusing on skeletal stem cells, vascular development, bone formation and the
translation from preclinical in vivo models to clinical delivery.