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2016 ; 11
(7
): 1282-1296
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Bone Disease after Kidney Transplantation
#MMPMID26912549
Bouquegneau A
; Salam S
; Delanaye P
; Eastell R
; Khwaja A
Clin J Am Soc Nephrol
2016[Jul]; 11
(7
): 1282-1296
PMID26912549
show ga
Bone and mineral disorders occur frequently in kidney transplant recipients and
are associated with a high risk of fracture, morbidity, and mortality. There is a
broad spectrum of often overlapping bone diseases seen after transplantation,
including osteoporosis as well as persisting high- or low-turnover bone disease.
The pathophysiology underlying bone disorders after transplantation results from
a complex interplay of factors, including preexisting renal osteodystrophy and
bone loss related to a variety of causes, such as immunosuppression and
alterations in the parathyroid hormone-vitamin D-fibroblast growth factor 23 axis
as well as changes in mineral metabolism. Management is complex, because
noninvasive tools, such as imaging and bone biomarkers, do not have sufficient
sensitivity and specificity to detect these abnormalities in bone structure and
function, whereas bone biopsy is not a widely available diagnostic tool. In this
review, we focus on recent data that highlight improvements in our understanding
of the prevalence, pathophysiology, and diagnostic and therapeutic strategies of
mineral and bone disorders in kidney transplant recipients.
|Absorptiometry, Photon
[MESH]
|Bone Density Conservation Agents/*therapeutic use
[MESH]
free
free
free
