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2014 ; 45
(8
): 646-52
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Blood-brain barrier imaging in human neuropathologies
#MMPMID25453223
Veksler R
; Shelef I
; Friedman A
Arch Med Res
2014[Nov]; 45
(8
): 646-52
PMID25453223
show ga
The blood-brain barrier (BBB) is essential for normal function of the brain, and
its role in many brain pathologies has been the focus of numerous studies during
the last decades. Dysfunction of the BBB is not only being shown in numerous
brain diseases, but animal studies have indicated that it plays a direct key role
in the genesis of neurovascular dysfunction and associated neurodegeneration. As
such evidence accumulates, the need for robust and clinically applicable methods
for minimally invasive assessment of BBB integrity is becoming urgent. This
review provides an introduction to BBB imaging methods in the clinical scenario.
First, imaging modalities are reviewed, with a focus on dynamic contrast-enhanced
magnetic resonance imaging (DCE-MRI). We then proceed to review image analysis
methods, including quantitative and semi-quantitative methods. The advantages and
limitations of each approach are discussed, and future directions and questions
are highlighted.
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