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10.18632/oncotarget.8251 http://scihub22266oqcxt.onion/10.18632/oncotarget.8251 C5008408!5008408 !27013582     free     free     free Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=27013582 &cmd=llinks): Failed to open stream: HTTP request failed! HTTP/1.1 429 Too Many Requests in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 215 Deprecated: Implicit conversion from float 229.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 229.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\27013582 .jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117       Oncotarget 2016 ; 7 (16 ): 22873-82 Nephropedia Template TP {{tp|p=27013582 |t=2016. Blockage of autophagy pathway enhances Salmonella tumor-targeting |pdf=|usr=}}{{27013582 }} gab.com Text Blockage of autophagy pathway enhances Salmonella tumor-targeting JO: Oncotarget http://www.kidney.de/pget.php?&tw=1&pmid=27013582 #FOAvip Previous studies have shown that strains of Salmonella typhimurium specifically target tumors in mouse models of cancer. In this study, we report that tumor-targeting Salmonella typhimurium A1-R (A1-R) or VNP20009 induced autophagy in human cancer cells, which serves as a defense response. Functionally, by knockdown of essential autophagy genes Atg5 or Beclin1 in bacteria-infected cancer cells, the autophagy pathway was blocked, which led to a significant increase of intracellular bacteria multiplication in cancer cells. Genetic inactivation of the autophagy pathway enhanced A1-R or VNP20009-mediated cancer cell killing by increasing apoptotic activity. We also demonstrate that the combination of pharmacological autophagy inhibitors chloroquine (CQ) or bafilomycin A1 (Baf A1) with tumor-targeting A1-R or VNP20009 significantly enhanced cancer-cell killing compared with Salmonella infection alone. These findings provide a proof-of-concept of combining autophagy inhibitors and tumor-targeting Salmonella to enhance cancer-cell killing. Twit Text FOAVip Blockage of autophagy pathway enhances Salmonella tumor-targeting ????Oncotarget http://www.kidney.de/pget.php?&tw=1&pmid=27013582 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=27013582 #FOAvip English Wikipedia <ref>{{Cite pmid|27013582 }}</ref> Blockage of autophagy pathway enhances Salmonella tumor-targeting #MMPMID27013582 Liu B ; Jiang Y ; Dong T ; Zhao M ; Wu J ; Li L ; Chu Y ; She S ; Zhao H ; Hoffman RM ; Jia L Oncotarget 2016[Apr]; 7 (16 ): 22873-82 PMID27013582 show ga Previous studies have shown that strains of Salmonella typhimurium specifically target tumors in mouse models of cancer. In this study, we report that tumor-targeting Salmonella typhimurium A1-R (A1-R) or VNP20009 induced autophagy in human cancer cells, which serves as a defense response. Functionally, by knockdown of essential autophagy genes Atg5 or Beclin1 in bacteria-infected cancer cells, the autophagy pathway was blocked, which led to a significant increase of intracellular bacteria multiplication in cancer cells. Genetic inactivation of the autophagy pathway enhanced A1-R or VNP20009-mediated cancer cell killing by increasing apoptotic activity. We also demonstrate that the combination of pharmacological autophagy inhibitors chloroquine (CQ) or bafilomycin A1 (Baf A1) with tumor-targeting A1-R or VNP20009 significantly enhanced cancer-cell killing compared with Salmonella infection alone. These findings provide a proof-of-concept of combining autophagy inhibitors and tumor-targeting Salmonella to enhance cancer-cell killing. |*Autophagy [MESH] |*Salmonella Infections [MESH] |Antineoplastic Agents/*pharmacology [MESH] |Cell Line, Tumor [MESH] |Humans [MESH] |Neoplasms/*microbiology [MESH]Blockage of autophagy pathway enhances Salmonella tumor-targeting (epmc).pdf DeepDyve Pubget Overpricing