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2016 ; 175
(1
): 12-23
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Bleeding related to disturbed fibrinolysis
#MMPMID27477022
Kolev K
; Longstaff C
Br J Haematol
2016[Oct]; 175
(1
): 12-23
PMID27477022
show ga
The components and reactions of the fibrinolysis system are well understood. The
pathway has fewer reactants and interactions than coagulation, but the generation
of a complete quantitative model is complicated by the need to work at the
solid-liquid interface of fibrin. Diagnostic tools to detect disease states due
to malfunctions in the fibrinolysis pathway are also not so well developed as is
the case with coagulation. However, there are clearly a number of inherited or
acquired pathologies where hyperfibrinolysis is a serious, potentially
life-threatening problem and a number of antifibrinolytc drugs are available to
treat hyperfibrinolysis. These topics will be covered in the following review.
|*Fibrinolysis
[MESH]
|Animals
[MESH]
|Antifibrinolytic Agents/pharmacology/therapeutic use
[MESH]