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2016 ; 12
(Suppl 1
): 17-23
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Bipartite Graphs for Visualization Analysis of Microbiome Data
#MMPMID27279729
Sedlar K
; Videnska P
; Skutkova H
; Rychlik I
; Provaznik I
Evol Bioinform Online
2016[]; 12
(Suppl 1
): 17-23
PMID27279729
show ga
Visualization analysis plays an important role in metagenomics research. Proper
and clear visualization can help researchers get their first insights into data
and by selecting different features, also revealing and highlighting hidden
relationships and drawing conclusions. To prevent the resulting presentations
from becoming chaotic, visualization techniques have to properly tackle the high
dimensionality of microbiome data. Although a number of different methods based
on dimensionality reduction, correlations, Venn diagrams, and network
representations have already been published, there is still room for further
improvement, especially in the techniques that allow visual comparison of several
environments or developmental stages in one environment. In this article, we
represent microbiome data by bipartite graphs, where one partition stands for
taxa and the other stands for samples. We demonstrated that community detection
is independent of taxonomical level. Moreover, focusing on higher taxonomical
levels and the appropriate merging of samples greatly helps improving graph
organization and makes our presentations clearer than other graph and network
visualizations. Capturing labels in the vertices also brings the possibility of
clearly comparing two or more microbial communities by showing their common and
unique parts.