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2020 ; 5
(19
): 10987-10994
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Biostudy on Traditional Chinese Medicine Massa Medicata Fermentata
#MMPMID32455219
Fu FQ
; Xu M
; Wei Z
; Li W
ACS Omega
2020[May]; 5
(19
): 10987-10994
PMID32455219
show ga
Massa Medicata Fermentata (MMF) has been used for a long time by the Chinese. MMF
is used widely in feed additives and human medicinal applications throughout the
world; however, there have only been a few reports about the biostudy of its
fermentation mechanism and medicinal ingredients. To safely use MMF, we observed
the changes in the ingredients and amylase activity for several raw materials
during the fermentation process of MMF. We are going to explore the basis of
pharmacodynamic substances and the purpose of MMF to provide support for safe use
in clinics. This biostudy data demonstrated that the ingredients such as
amygdalin, benzaldehyde, and rutin were gradually degraded during the process of
fermentation, and the fermented MMF did not contain amygdalin and benzaldehyde.
The HPLC fingerprint of fermented MMF for 7 days is similar to the chemical
composition of the original unfermented MMF with a similarity of only 0.106.
Meanwhile, the activities of amylase in fermented MMF had gradually increased,
and the content of organic acids also had increased. According to our biostudy,
we found that the raw material chemical composition of MMF in the process of
fermentation was affected by microorganisms and various substances. The
conclusions of our study determined that the initial components of MMF are not
identical to the pharmacodynamic components. We also conclude that amylase
activity explains the pharmacological activity of MMF to a certain extent, but it
is likely not the only factor. The implication not only provides the initial
knowledge of MMF but also implies the further exploration of this popular
traditional medicine.
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