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10.1016/j.addr.2014.02.011 http://scihub22266oqcxt.onion/10.1016/j.addr.2014.02.011 C4144187!4144187 !24607703     free     free     free Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\24607703 .jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117       Adv+Drug+Deliv+Rev 2014 ; 69-70 (ä): 132-57 Nephropedia Template TP {{tp|p=24607703 |t=2014. Bioreactor technologies to support liver function in vitro |pdf=|usr=}}{{24607703 }} gab.com Text Bioreactor technologies to support liver function in vitro JO: Adv Drug Deliv Rev http://www.kidney.de/pget.php?&tw=1&pmid=24607703 #FOAvip Liver is a central nexus integrating metabolic and immunologic homeostasis in the human body, and the direct or indirect target of most molecular therapeutics. A wide spectrum of therapeutic and technological needs drives efforts to capture liver physiology and pathophysiology in vitro, ranging from prediction of metabolism and toxicity of small molecule drugs, to understanding off-target effects of proteins, nucleic acid therapies, and targeted therapeutics, to serving as disease models for drug development. Here we provide perspective on the evolving landscape of bioreactor-based models to meet old and new challenges in drug discovery and development, emphasizing design challenges in maintaining long-term liver-specific function and how emerging technologies in biomaterials and microdevices are providing new experimental models. Twit Text FOAVip Bioreactor technologies to support liver function in vitro ????Adv Drug Deliv Rev http://www.kidney.de/pget.php?&tw=1&pmid=24607703 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=24607703 #FOAvip English Wikipedia <ref>{{Cite pmid|24607703 }}</ref> Bioreactor technologies to support liver function in vitro #MMPMID24607703 Ebrahimkhani MR ; Neiman JA ; Raredon MS ; Hughes DJ ; Griffith LG Adv Drug Deliv Rev 2014[Apr]; 69-70 (ä): 132-57 PMID24607703 show ga Liver is a central nexus integrating metabolic and immunologic homeostasis in the human body, and the direct or indirect target of most molecular therapeutics. A wide spectrum of therapeutic and technological needs drives efforts to capture liver physiology and pathophysiology in vitro, ranging from prediction of metabolism and toxicity of small molecule drugs, to understanding off-target effects of proteins, nucleic acid therapies, and targeted therapeutics, to serving as disease models for drug development. Here we provide perspective on the evolving landscape of bioreactor-based models to meet old and new challenges in drug discovery and development, emphasizing design challenges in maintaining long-term liver-specific function and how emerging technologies in biomaterials and microdevices are providing new experimental models. |*Bioreactors [MESH] |Animals [MESH] |Cell Culture Techniques/*methods/trends [MESH] |Hepatocytes/*physiology [MESH] |Humans [MESH] |Liver/*physiology [MESH]Bioreactor technologies to support liver function in vitro (epmc).pdf DeepDyve Pubget Overpricing