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2016 ; 64
(6
): 415-21
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Biopsy techniques for intraocular tumors
#MMPMID27488148
Rishi P
; Dhami A
; Biswas J
Indian J Ophthalmol
2016[Jun]; 64
(6
): 415-21
PMID27488148
show ga
Biopsy involves the surgical removal of a tissue specimen for histopathologic
evaluation. Most intraocular tumors are reliably diagnosed based on the clinical
evaluation or with noninvasive diagnostic techniques. However, accurately
diagnosing a small percentage of tumors can be challenging. A tissue biopsy is
thus needed to establish a definitive diagnosis and plan the requisite treatment.
From fine-needle aspiration biopsy (FNAB) to surgical excision, all tissue
collection techniques have been studied in the literature. Each technique has its
indications and limitations. FNAB has been reported to provide for 88-95%
reliable and safe ophthalmic tumor diagnosis and has gained popularity for
prognostic purposes and providing eye conserving treatment surgeries. The
technique and instrumentation for biopsy vary depending upon the tissue involved
(retina, choroid, subretinal space, vitreous, and aqueous), suspected diagnosis,
size, location, associated retinal detachment, and clarity of the media. The
cytopathologist confers a very important role in diagnosis and their assistance
plays a key role in managing and planning the treatment for malignancies.
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