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10.1038/nmat4644 http://scihub22266oqcxt.onion/10.1038/nmat4644 C5127392!5127392 !27213956     free     free     free Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\27213956 .jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117       Nat+Mater 2016 ; 15 (9 ): 1037-46 Nephropedia Template TP {{tp|p=27213956 |t=2016. Biomimetic proteolipid vesicles for targeting inflamed tissues |pdf=|usr=}}{{27213956 }} gab.com Text Biomimetic proteolipid vesicles for targeting inflamed tissues JO: Nat Mater http://www.kidney.de/pget.php?&tw=1&pmid=27213956 #FOAvip A multitude of micro- and nanoparticles have been developed to improve the delivery of systemically administered pharmaceuticals, which are subject to a number of biological barriers that limit their optimal biodistribution. Bioinspired drug-delivery carriers formulated by bottom-up or top-down strategies have emerged as an alternative approach to evade the mononuclear phagocytic system and facilitate transport across the endothelial vessel wall. Here, we describe a method that leverages the advantages of bottom-up and top-down strategies to incorporate proteins derived from the leukocyte plasma membrane into lipid nanoparticles. The resulting proteolipid vesicles-which we refer to as leukosomes-retained the versatility and physicochemical properties typical of liposomal formulations, preferentially targeted inflamed vasculature, enabled the selective and effective delivery of dexamethasone to inflamed tissues, and reduced phlogosis in a localized model of inflammation. Twit Text FOAVip Biomimetic proteolipid vesicles for targeting inflamed tissues ????Nat Mater http://www.kidney.de/pget.php?&tw=1&pmid=27213956 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=27213956 #FOAvip English Wikipedia <ref>{{Cite pmid|27213956 }}</ref> Biomimetic proteolipid vesicles for targeting inflamed tissues #MMPMID27213956 Molinaro R ; Corbo C ; Martinez JO ; Taraballi F ; Evangelopoulos M ; Minardi S ; Yazdi IK ; Zhao P ; De Rosa E ; Sherman MB ; De Vita A ; Toledano Furman NE ; Wang X ; Parodi A ; Tasciotti E Nat Mater 2016[Sep]; 15 (9 ): 1037-46 PMID27213956 show ga A multitude of micro- and nanoparticles have been developed to improve the delivery of systemically administered pharmaceuticals, which are subject to a number of biological barriers that limit their optimal biodistribution. Bioinspired drug-delivery carriers formulated by bottom-up or top-down strategies have emerged as an alternative approach to evade the mononuclear phagocytic system and facilitate transport across the endothelial vessel wall. Here, we describe a method that leverages the advantages of bottom-up and top-down strategies to incorporate proteins derived from the leukocyte plasma membrane into lipid nanoparticles. The resulting proteolipid vesicles-which we refer to as leukosomes-retained the versatility and physicochemical properties typical of liposomal formulations, preferentially targeted inflamed vasculature, enabled the selective and effective delivery of dexamethasone to inflamed tissues, and reduced phlogosis in a localized model of inflammation. |Biomimetic Materials/*metabolism [MESH] |Drug Carriers/*metabolism [MESH] |Inflammation/pathology [MESH] |Leukocytes/cytology [MESH] |Membrane Proteins/metabolism [MESH]Biomimetic proteolipid vesicles for targeting inflamed tissues (epmc).pdf DeepDyve Pubget Overpricing