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10.1038/s41598-017-04316-1

http://scihub22266oqcxt.onion/10.1038/s41598-017-04316-1
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suck abstract from ncbi


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pmid28642488
      Sci+Rep 2017 ; 7 (1 ): 4081
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  • Biomimetic Molecular Signaling using DNA Walkers on Microparticles #MMPMID28642488
  • Damase TR ; Spencer A ; Samuel B ; Allen PB
  • Sci Rep 2017[Jun]; 7 (1 ): 4081 PMID28642488 show ga
  • We report the release of catalytic DNA walkers from hydrogel microparticles and the detection of those walkers by substrate-coated microparticles. This might be considered a synthetic biology analog of molecular signal release and reception. One type of particles was coated with components of a DNA one-step strand displacement (OSD) reaction to release the walker. A second type of particle was coated with substrate (or "track") for the molecular walker. We distinguish these particle types using fluorescence barcoding: we synthesized and distinguished multiple particle types with multicolor fluorescence microscopy and automated image analysis software. This represents a step toward amplified, multiplex, and microscopically localized detection based on DNA nanotechnology.
  • |*Biomimetics/methods [MESH]
  • |DNA, Catalytic [MESH]
  • |DNA/*chemistry [MESH]
  • |Fluorescent Dyes [MESH]
  • |Hydrogels/chemistry [MESH]
  • |Nanoparticles/*chemistry [MESH]


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