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2015 ; 4
(9
): 1268-85
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Biomaterials for Bone Regenerative Engineering
#MMPMID25846250
Yu X
; Tang X
; Gohil SV
; Laurencin CT
Adv Healthc Mater
2015[Jun]; 4
(9
): 1268-85
PMID25846250
show ga
Strategies for bone tissue regeneration have been continuously evolving for the
last 25 years since the introduction of the "tissue engineering" concept. The
convergence of the life, physical, and engineering sciences has brought in
several advanced technologies available to tissue engineers and scientists. This
resulted in the creation of a new multidisciplinary field termed as "regenerative
engineering". In this article, the role of biomaterials in bone regenerative
engineering is systematically reviewed to elucidate the new design criteria for
the next generation of biomaterials for bone regenerative engineering. The
exemplary design of biomaterials harnessing various materials characteristics
towards successful bone defect repair and regeneration is highlighted. Particular
attention is given to the attempts of incorporating advanced materials science,
stem cell technologies, and developmental biology into biomaterials design to
engineer and develop the next generation bone grafts.
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