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http://scihub22266oqcxt.onion/ C4464432!4464432 !26417296     free     free     free Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=26417296 &cmd=llinks): Failed to open stream: HTTP request failed! HTTP/1.1 429 Too Many Requests in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 215       EXCLI+J 2014 ; 13 (?): 728-39 Nephropedia Template TP {{tp|p=26417296 |t=2014. Biology of PXR: role in drug-hormone interactions |pdf=|usr=}}{{26417296 }} gab.com Text Biology of PXR: role in drug-hormone interactions JO: EXCLI J http://www.kidney.de/pget.php?&tw=1&pmid=26417296 #FOAvip Hormonal homeostasis is essential for a variety of physiological and pathological processes. Elimination and detoxification of xenobiotics, such as drugs introduced into the human body, could disrupt the balance of hormones due to the induction of drug metabolizing enzymes (DMEs) and transporters. Pregnane X receptor (PXR, NR1I2) functions as a master xenobiotic receptor involved in drug metabolism and drug-drug interactions by its coordinated transcriptional regulation of phase I and phase II DMEs and transporters. Recently, increasing evidences indicate that PXR can also mediate the endocrine disruptor function and thus impact the integrity of the endocrine system. This review focuses primarily on the recent advances in our understanding of the function of PXR in glucocorticoid, mineralocorticoid, androgen and estrogen homeostasis. The elucidation of PXR-mediated drug-hormone interactions might have important therapeutic implications in dealing with hormone-dependent diseases and safety assessment of drugs. Twit Text FOAVip Biology of PXR: role in drug-hormone interactions ????EXCLI J http://www.kidney.de/pget.php?&tw=1&pmid=26417296 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=26417296 #FOAvip English Wikipedia <ref>{{Cite pmid|26417296 }}</ref> Biology of PXR: role in drug-hormone interactions #MMPMID26417296 Wang J ; Dai S ; Guo Y ; Xie W ; Zhai Y EXCLI J 2014[]; 13 (?): 728-39 PMID26417296 show ga Hormonal homeostasis is essential for a variety of physiological and pathological processes. Elimination and detoxification of xenobiotics, such as drugs introduced into the human body, could disrupt the balance of hormones due to the induction of drug metabolizing enzymes (DMEs) and transporters. Pregnane X receptor (PXR, NR1I2) functions as a master xenobiotic receptor involved in drug metabolism and drug-drug interactions by its coordinated transcriptional regulation of phase I and phase II DMEs and transporters. Recently, increasing evidences indicate that PXR can also mediate the endocrine disruptor function and thus impact the integrity of the endocrine system. This review focuses primarily on the recent advances in our understanding of the function of PXR in glucocorticoid, mineralocorticoid, androgen and estrogen homeostasis. The elucidation of PXR-mediated drug-hormone interactions might have important therapeutic implications in dealing with hormone-dependent diseases and safety assessment of drugs. ?Biology of PXR: role in drug-hormone interactions (epmc).pdf DeepDyve Pubget Overpricing