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10.1016/j.injury.2014.04.003 http://scihub22266oqcxt.onion/10.1016/j.injury.2014.04.003 C4406220!4406220 !24857030     free     free     free Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=24857030 &cmd=llinks): Failed to open stream: HTTP request failed! HTTP/1.1 429 Too Many Requests in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 215 Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\24857030 .jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117       Injury 2014 ; 45 Suppl 2 (0 2 ): S8-S15 Nephropedia Template TP {{tp|p=24857030 |t=2014. Biological perspectives of delayed fracture healing |pdf=|usr=}}{{24857030 }} gab.com Text Biological perspectives of delayed fracture healing JO: Injury http://www.kidney.de/pget.php?&tw=1&pmid=24857030 #FOAvip Fracture healing is a complex biological process that requires interaction among a series of different cell types. Maintaining the appropriate temporal progression and spatial pattern is essential to achieve robust healing. We can temporally assess the biological phases via gene expression, protein analysis, histologically, or non-invasively using biomarkers as well as imaging techniques. However, determining what leads to normal versus abnormal healing is more challenging. Since the ultimate outcome of fracture healing is to restore the original functions of bone, assessment of fracture healing should include not only monitoring the restoration of structure and mechanical function, but also an evaluation of the restoration of normal bone biology. Currently few non-invasive measures of biological factors of healing exist; however, recent studies that have correlated non-invasive measures with fracture healing outcome in humans have shown that serum TGFbeta1 levels appear to be an indicator of healing versus non-healing. In the future, developing additional measures to assess biological healing will improve the reliability and permit us to assess stages of fracture healing. Additionally, new functional imaging technologies could prove useful for better understanding both normal fracture healing and predicting dysfunctional healing in human patients. Twit Text FOAVip Biological perspectives of delayed fracture healing ????Injury http://www.kidney.de/pget.php?&tw=1&pmid=24857030 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=24857030 #FOAvip English Wikipedia <ref>{{Cite pmid|24857030 }}</ref> Biological perspectives of delayed fracture healing #MMPMID24857030 Hankenson KD ; Zimmerman G ; Marcucio R Injury 2014[Jun]; 45 Suppl 2 (0 2 ): S8-S15 PMID24857030 show ga Fracture healing is a complex biological process that requires interaction among a series of different cell types. Maintaining the appropriate temporal progression and spatial pattern is essential to achieve robust healing. We can temporally assess the biological phases via gene expression, protein analysis, histologically, or non-invasively using biomarkers as well as imaging techniques. However, determining what leads to normal versus abnormal healing is more challenging. Since the ultimate outcome of fracture healing is to restore the original functions of bone, assessment of fracture healing should include not only monitoring the restoration of structure and mechanical function, but also an evaluation of the restoration of normal bone biology. Currently few non-invasive measures of biological factors of healing exist; however, recent studies that have correlated non-invasive measures with fracture healing outcome in humans have shown that serum TGFbeta1 levels appear to be an indicator of healing versus non-healing. In the future, developing additional measures to assess biological healing will improve the reliability and permit us to assess stages of fracture healing. Additionally, new functional imaging technologies could prove useful for better understanding both normal fracture healing and predicting dysfunctional healing in human patients. |Animals [MESH] |Biomarkers/blood [MESH] |Extracellular Matrix Proteins/*blood [MESH] |Fracture Healing/*physiology [MESH] |Fractures, Bone/*blood/*therapy [MESH] |Fractures, Ununited/blood [MESH] |Humans [MESH] |Mice [MESH] |Time Factors [MESH]Biological perspectives of delayed fracture healing (epmc).pdf DeepDyve Pubget Overpricing