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2018 ; 9
(ä): 299
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Biological Mechanisms of Cancer-Induced Depression
#MMPMID30042700
Young K
; Singh G
Front Psychiatry
2018[]; 9
(ä): 299
PMID30042700
show ga
Patients with cancer are more likely to develop depression than the general
population, which negatively impacts their quality of life and prognosis. In
order to identify effective antidepressants catered toward cancer patients, the
biology of depression in the context of cancer must be well-understood. Many
theories have emerged postulating the mechanisms underlying the development of
depressive disorder. Here, we review the role inflammation, a hyperactive
hypothalamic-pituitary-adrenal (HPA) axis, and glutamate excitotoxicity may play
in cancer-induced depression. Hopefully, novel therapeutics targeting these
dysregulated pathways may be potent in ameliorating depressive symptoms in the
cancer population.