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10.1038/srep26715 http://scihub22266oqcxt.onion/10.1038/srep26715 C4886219!4886219 !27242131     free     free     free Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=27242131 &cmd=llinks): Failed to open stream: HTTP request failed! HTTP/1.1 429 Too Many Requests in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 215 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\27242131 .jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117       Sci+Rep 2016 ; 6 (ä): 26715 Nephropedia Template TP {{tp|p=27242131 |t=2016. Bioengineered kidney tubules efficiently excrete uremic toxins |pdf=|usr=}}{{27242131 }} gab.com Text Bioengineered kidney tubules efficiently excrete uremic toxins JO: Sci Rep http://www.kidney.de/pget.php?&tw=1&pmid=27242131 #FOAvip The development of a biotechnological platform for the removal of waste products (e.g. uremic toxins), often bound to proteins in plasma, is a prerequisite to improve current treatment modalities for patients suffering from end stage renal disease (ESRD). Here, we present a newly designed bioengineered renal tubule capable of active uremic toxin secretion through the concerted action of essential renal transporters, viz. organic anion transporter-1 (OAT1), breast cancer resistance protein (BCRP) and multidrug resistance protein-4 (MRP4). Three-dimensional cell monolayer formation of human conditionally immortalized proximal tubule epithelial cells (ciPTEC) on biofunctionalized hollow fibers with maintained barrier function was demonstrated. Using a tailor made flow system, the secretory clearance of human serum albumin-bound uremic toxins, indoxyl sulfate and kynurenic acid, as well as albumin reabsorption across the renal tubule was confirmed. These functional bioengineered renal tubules are promising entities in renal replacement therapies and regenerative medicine, as well as in drug development programs. Twit Text FOAVip Bioengineered kidney tubules efficiently excrete uremic toxins ????Sci Rep http://www.kidney.de/pget.php?&tw=1&pmid=27242131 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=27242131 #FOAvip English Wikipedia <ref>{{Cite pmid|27242131 }}</ref> Bioengineered kidney tubules efficiently excrete uremic toxins #MMPMID27242131 Jansen J ; Fedecostante M ; Wilmer MJ ; Peters JG ; Kreuser UM ; van den Broek PH ; Mensink RA ; Boltje TJ ; Stamatialis D ; Wetzels JF ; van den Heuvel LP ; Hoenderop JG ; Masereeuw R Sci Rep 2016[May]; 6 (ä): 26715 PMID27242131 show ga The development of a biotechnological platform for the removal of waste products (e.g. uremic toxins), often bound to proteins in plasma, is a prerequisite to improve current treatment modalities for patients suffering from end stage renal disease (ESRD). Here, we present a newly designed bioengineered renal tubule capable of active uremic toxin secretion through the concerted action of essential renal transporters, viz. organic anion transporter-1 (OAT1), breast cancer resistance protein (BCRP) and multidrug resistance protein-4 (MRP4). Three-dimensional cell monolayer formation of human conditionally immortalized proximal tubule epithelial cells (ciPTEC) on biofunctionalized hollow fibers with maintained barrier function was demonstrated. Using a tailor made flow system, the secretory clearance of human serum albumin-bound uremic toxins, indoxyl sulfate and kynurenic acid, as well as albumin reabsorption across the renal tubule was confirmed. These functional bioengineered renal tubules are promising entities in renal replacement therapies and regenerative medicine, as well as in drug development programs. |*Tissue Engineering [MESH] |ATP Binding Cassette Transporter, Subfamily G, Member 2/genetics/*metabolism [MESH] |Cell Line [MESH] |Humans [MESH] |Kidney Failure, Chronic/genetics/metabolism/pathology [MESH] |Kidney Tubules, Proximal/*metabolism/pathology [MESH] |Multidrug Resistance-Associated Proteins/genetics/*metabolism [MESH] |Neoplasm Proteins/genetics/*metabolism [MESH]Bioengineered kidney tubules efficiently excrete uremic toxins (epmc).pdf DeepDyve Pubget Overpricing