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2014 ; 171
(8
): 1854-69
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Bioenergetic medicine
#MMPMID24004341
Swerdlow RH
Br J Pharmacol
2014[Apr]; 171
(8
): 1854-69
PMID24004341
show ga
Here we discuss a specific therapeutic strategy we call 'bioenergetic medicine'.
Bioenergetic medicine refers to the manipulation of bioenergetic fluxes to
positively affect health. Bioenergetic medicine approaches rely heavily on the
law of mass action, and impact systems that monitor and respond to the
manipulated flux. Since classically defined energy metabolism pathways intersect
and intertwine, targeting one flux also tends to change other fluxes, which
complicates treatment design. Such indirect effects, fortunately, are to some
extent predictable, and from a therapeutic perspective may also be desirable.
Bioenergetic medicine-based interventions already exist for some diseases, and
because bioenergetic medicine interventions are presently feasible, new
approaches to treat certain conditions, including some neurodegenerative
conditions and cancers, are beginning to transition from the laboratory to the
clinic.