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Lee CH
; Hsieh MJ
; Chang SH
; Chiang CL
; Fan CL
; Liu SJ
; Chen WJ
; Wang CJ
; Hsu MY
; Hung KC
; Chou CC
; Chang PC
Sci Rep
2017[Mar]; 7
(1
): 111
PMID28273914
show ga
"Cable-tie" type biodegradable stents with drug-eluting nanofiber were developed
to treat rabbit denuded arteries in this study. Biodegradable stents were
fabricated using poly-L-lactide film following being cut and rolled into a
cable-tie type stent. Additionally, drug-eluting biodegradable nanofiber tubes
were electrospun from a solution containing poly (lactic-co-glycolic acid),
rapamycin, and hexafluoroisopropanol, and then mounted onto the stents. The
fabricated rapamycin-eluting cable-tie stents exhibited excellent mechanical
properties on evaluation of compression test and collapse pressure, and less than
8% weight loss following being immersed in phosphate-buffered saline for 16
weeks. Furthermore, the biodegradable stents delivered high rapamycin
concentrations for over 4 weeks and achieved substantial reductions in intimal
hyperplasia associated with elevated heme oxygenase-1 and calponin level on the
denuded rabbit arteries during 6 months of follow-up. The drug-eluting cable-tie
type stents developed in this study might have high potential impacts for the
local drug delivery to treat various vascular diseases.
free
free
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