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10.1016/j.addr.2015.02.002 http://scihub22266oqcxt.onion/10.1016/j.addr.2015.02.002 C4504788!4504788 !25689735     free     free     free Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\25689735 .jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117       Adv+Drug+Deliv+Rev 2015 ; 87 (ä): 81-9 Nephropedia Template TP {{tp|p=25689735 |t=2015. Bioconjugates for targeted delivery of therapeutic oligonucleotides |pdf=|usr=}}{{25689735 }} gab.com Text Bioconjugates for targeted delivery of therapeutic oligonucleotides JO: Adv Drug Deliv Rev http://www.kidney.de/pget.php?&tw=1&pmid=25689735 #FOAvip Bioconjugates have been used to deliver therapeutic oligonucleotides to their pharmacological targets in diseased cells. Molecular-scale conjugates can be prepared by directly linking targeting ligands with oligonucleotides and the resultant conjugates can selectively bind to cell surface receptors in target cells in diseased tissues. Besides targeted delivery, additional functionality can be incorporated in the conjugates by utilization of carrier molecules, and these larger conjugates are called carrier-associated conjugates. Both molecular and carrier-associated conjugates have achieved initial successes in clinical trials for treating liver diseases; therefore, currently the greater challenge is to deliver oligonucleotides to extrahepatic tissues such as tumors. This review will provide an update on the application of oligonucleotide conjugates for targeted delivery during the last decade. By identifying key elements for successful delivery, it is suggested that oligonucleotide conjugates with intermediate size, cell targeting ability, and endosomal release functionality are superior systems to advance oligonucleotides to achieve their full therapeutic potentials. Twit Text FOAVip Bioconjugates for targeted delivery of therapeutic oligonucleotides ????Adv Drug Deliv Rev http://www.kidney.de/pget.php?&tw=1&pmid=25689735 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=25689735 #FOAvip English Wikipedia <ref>{{Cite pmid|25689735 }}</ref> Bioconjugates for targeted delivery of therapeutic oligonucleotides #MMPMID25689735 Ming X ; Laing B Adv Drug Deliv Rev 2015[Jun]; 87 (ä): 81-9 PMID25689735 show ga Bioconjugates have been used to deliver therapeutic oligonucleotides to their pharmacological targets in diseased cells. Molecular-scale conjugates can be prepared by directly linking targeting ligands with oligonucleotides and the resultant conjugates can selectively bind to cell surface receptors in target cells in diseased tissues. Besides targeted delivery, additional functionality can be incorporated in the conjugates by utilization of carrier molecules, and these larger conjugates are called carrier-associated conjugates. Both molecular and carrier-associated conjugates have achieved initial successes in clinical trials for treating liver diseases; therefore, currently the greater challenge is to deliver oligonucleotides to extrahepatic tissues such as tumors. This review will provide an update on the application of oligonucleotide conjugates for targeted delivery during the last decade. By identifying key elements for successful delivery, it is suggested that oligonucleotide conjugates with intermediate size, cell targeting ability, and endosomal release functionality are superior systems to advance oligonucleotides to achieve their full therapeutic potentials. |Animals [MESH] |Drug Carriers/*chemistry/metabolism [MESH] |Drug Delivery Systems [MESH] |Humans [MESH] |Ligands [MESH] |Nanoconjugates/*chemistry [MESH] |Oligonucleotides/*administration & dosage/metabolism [MESH] |Protein Binding [MESH]Bioconjugates for targeted delivery of therapeutic oligonucleotides (epmc).pdf DeepDyve Pubget Overpricing