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Bioabsorbable polymer optical waveguides for deep-tissue photomedicine
#MMPMID26783091
Nizamoglu S
; Gather MC
; Humar M
; Choi M
; Kim S
; Kim KS
; Hahn SK
; Scarcelli G
; Randolph M
; Redmond RW
; Yun SH
Nat Commun
2016[Jan]; 7
(?): 10374
PMID26783091
show ga
Advances in photonics have stimulated significant progress in medicine, with many
techniques now in routine clinical use. However, the finite depth of light
penetration in tissue is a serious constraint to clinical utility. Here we show
implantable light-delivery devices made of bio-derived or biocompatible, and
biodegradable polymers. In contrast to conventional optical fibres, which must be
removed from the body soon after use, the biodegradable and biocompatible
waveguides may be used for long-term light delivery and need not be removed as
they are gradually resorbed by the tissue. As proof of concept, we demonstrate
this paradigm-shifting approach for photochemical tissue bonding (PTB). Using
comb-shaped planar waveguides, we achieve a full thickness (>10 mm) wound closure
of porcine skin, which represents ? 10-fold extension of the tissue area achieved
with conventional PTB. The results point to a new direction in photomedicine for
using light in deep tissues.
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