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10.1016/j.addr.2017.05.012 http://scihub22266oqcxt.onion/10.1016/j.addr.2017.05.012 C5581997!5581997 !28532691     free     free     free Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\28532691 .jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117       Adv+Drug+Deliv+Rev 2017 ; 114 (ä): 266-271 Nephropedia Template TP {{tp|p=28532691 |t=2017. Bio-synthetic materials for immunomodulation of islet transplants |pdf=|usr=}}{{28532691 }} gab.com Text Bio-synthetic materials for immunomodulation of islet transplants JO: Adv Drug Deliv Rev http://www.kidney.de/pget.php?&tw=1&pmid=28532691 #FOAvip Clinical islet transplantation is an effective therapy in restoring physiological glycemic control in type 1 diabetics. However, allogeneic islets derived from cadaveric sources elicit immune responses that result in acute and chronic islet destruction. To prevent immune destruction of islets, transplant recipients require lifelong delivery of immunosuppressive drugs, which are associated with debilitating side effects. Biomaterial-based strategies to eliminate the need for immunosuppressive drugs are an emerging therapy for improving islet transplantation. In this context, two main approaches have been used: 1) encapsulation of islets to prevent infiltration and contact of immune cells, and 2) local release of immunomodulatory molecules from biomaterial systems that suppress local immunity. Synthetic biomaterials provide excellent control over material properties, molecule presentation, and therapeutic release, and thus, are an emerging platform for immunomodulation to facilitate islet transplantation. This review highlights various synthetic biomaterial-based strategies for preventing immune rejection of islet allografts. Twit Text FOAVip Bio-synthetic materials for immunomodulation of islet transplants ????Adv Drug Deliv Rev http://www.kidney.de/pget.php?&tw=1&pmid=28532691 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=28532691 #FOAvip English Wikipedia <ref>{{Cite pmid|28532691 }}</ref> Bio-synthetic materials for immunomodulation of islet transplants #MMPMID28532691 Foster GA ; García AJ Adv Drug Deliv Rev 2017[May]; 114 (ä): 266-271 PMID28532691 show ga Clinical islet transplantation is an effective therapy in restoring physiological glycemic control in type 1 diabetics. However, allogeneic islets derived from cadaveric sources elicit immune responses that result in acute and chronic islet destruction. To prevent immune destruction of islets, transplant recipients require lifelong delivery of immunosuppressive drugs, which are associated with debilitating side effects. Biomaterial-based strategies to eliminate the need for immunosuppressive drugs are an emerging therapy for improving islet transplantation. In this context, two main approaches have been used: 1) encapsulation of islets to prevent infiltration and contact of immune cells, and 2) local release of immunomodulatory molecules from biomaterial systems that suppress local immunity. Synthetic biomaterials provide excellent control over material properties, molecule presentation, and therapeutic release, and thus, are an emerging platform for immunomodulation to facilitate islet transplantation. This review highlights various synthetic biomaterial-based strategies for preventing immune rejection of islet allografts. |*Immunomodulation [MESH] |Animals [MESH] |Biocompatible Materials/*therapeutic use [MESH] |Graft Rejection/immunology/*prevention & control [MESH] |Humans [MESH] |Immunosuppression Therapy/*methods [MESH]Bio-synthetic materials for immunomodulation of islet transplants (epmc).pdf DeepDyve Pubget Overpricing