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2014 ; 8
(4
): 349-59
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Beyond boundaries--Eph:ephrin signaling in neurogenesis
#MMPMID25482631
Laussu J
; Khuong A
; Gautrais J
; Davy A
Cell Adh Migr
2014[]; 8
(4
): 349-59
PMID25482631
show ga
Eph:ephrin signaling plays an important role in embryonic development as well as
tissue homeostasis in the adult. At the cellular level, this transduction pathway
is best known for its role in the control of cell adhesion and repulsion, cell
migration and morphogenesis. Yet, a number of publications have also implicated
Eph:ephrin signaling in the control of adult and embryonic neurogenesis. As is
the case for other biological processes, these studies have reported conflicting
and sometimes opposite roles for Eph:ephrin signaling in neurogenesis. Herein, we
review these studies and we discuss existing mathematical models of stem cell
dynamics and neurogenesis that provide a coherent framework and may help
reconcile conflicting results.