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2016 ; 63
(1
): 89-95
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Beyond Antibiotics: New Therapeutic Approaches for Bacterial Infections
#MMPMID27025826
Hauser AR
; Mecsas J
; Moir DT
Clin Infect Dis
2016[Jul]; 63
(1
): 89-95
PMID27025826
show ga
The utility of conventional antibiotics for the treatment of bacterial infections
has become increasingly strained due to increased rates of resistance coupled
with reduced rates of development of new agents. As a result,
multidrug-resistant, extensively drug-resistant, and pandrug-resistant bacterial
strains are now frequently encountered. This has led to fears of a
"postantibiotic era" in which many bacterial infections will be untreatable.
Alternative nonantibiotic treatment strategies need to be explored to ensure that
a robust pipeline of effective therapies is available to clinicians. In this
review, we highlight some of the recent developments in this area, such as the
targeting of bacterial virulence factors, utilization of bacteriophages to kill
bacteria, and manipulation of the microbiome to combat infections.