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10.18632/oncoscience.357

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suck abstract from ncbi


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pmid28966942
      Oncoscience 2017 ; 4 (7-8 ): 95-105
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  • Beta-adrenergic receptors are expressed across diverse cancers #MMPMID28966942
  • Rains SL ; Amaya CN ; Bryan BA
  • Oncoscience 2017[Jul]; 4 (7-8 ): 95-105 PMID28966942 show ga
  • Based largely on retrospective analyses and a handful of prospective case reports, pharmacological inhibition of the beta adrenergic receptors using beta blockers has shown clinical anti-cancer efficacy in reproductive cancers, as well as angiosarcoma and multiple myeloma. Because of the potential promise of beta blockers as an adjunct to standard anti-cancer therapy, it is imperative to identify other tumor types expressing beta adrenergic (?-AR) receptors so future preclinical and clinical studies can be directed at the most promising tumor targets. We performed immunohistochemical detection of ?1-AR, ?2-AR, and ?3-AR across 29 of the most common human cancer types (389 tissues total) and 19 matching non-diseased controls (100 tissues total). Our analysis revealed all three ?-AR receptors were expressed most strongly in melanoma relative to other cancer types. Other malignancies that revealed relatively higher levels of ?-AR receptors were esophagus, pancreas, kidney, and lung cancers. Moreover, particular ?-AR receptors exhibited significant overexpression in tumor tissue relative to their matching normal tissue in urogenital/reproductive malignancies including breast, endometrium, ovarian, and urothelial cancer, as well as colon, lung, and thyroid cancer. This study identifies several cancer types expressing the ?-AR receptors which should be evaluated in future studies for susceptibility to beta blockade.
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