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2017 ; 4
(7-8
): 95-105
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Beta-adrenergic receptors are expressed across diverse cancers
#MMPMID28966942
Rains SL
; Amaya CN
; Bryan BA
Oncoscience
2017[Jul]; 4
(7-8
): 95-105
PMID28966942
show ga
Based largely on retrospective analyses and a handful of prospective case
reports, pharmacological inhibition of the beta adrenergic receptors using beta
blockers has shown clinical anti-cancer efficacy in reproductive cancers, as well
as angiosarcoma and multiple myeloma. Because of the potential promise of beta
blockers as an adjunct to standard anti-cancer therapy, it is imperative to
identify other tumor types expressing beta adrenergic (?-AR) receptors so future
preclinical and clinical studies can be directed at the most promising tumor
targets. We performed immunohistochemical detection of ?1-AR, ?2-AR, and ?3-AR
across 29 of the most common human cancer types (389 tissues total) and 19
matching non-diseased controls (100 tissues total). Our analysis revealed all
three ?-AR receptors were expressed most strongly in melanoma relative to other
cancer types. Other malignancies that revealed relatively higher levels of ?-AR
receptors were esophagus, pancreas, kidney, and lung cancers. Moreover,
particular ?-AR receptors exhibited significant overexpression in tumor tissue
relative to their matching normal tissue in urogenital/reproductive malignancies
including breast, endometrium, ovarian, and urothelial cancer, as well as colon,
lung, and thyroid cancer. This study identifies several cancer types expressing
the ?-AR receptors which should be evaluated in future studies for susceptibility
to beta blockade.