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10.4161/auto.29746 http://scihub22266oqcxt.onion/10.4161/auto.29746 C4198362!4198362 !25126729     free     free     free Deprecated: Implicit conversion from float 219.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 219.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 219.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\25126729 .jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117       Autophagy 2014 ; 10 (10 ): 1776-86 Nephropedia Template TP {{tp|p=25126729 |t=2014. Berberine attenuates autophagy in adipocytes by targeting BECN1 |pdf=|usr=}}{{25126729 }} gab.com Text Berberine attenuates autophagy in adipocytes by targeting BECN1 JO: Autophagy http://www.kidney.de/pget.php?&tw=1&pmid=25126729 #FOAvip The lysosomal degradation pathway, autophagy, is essential for the maintenance of cellular homeostasis. Recently, autophagy has been demonstrated to be required in the process of adipocyte conversion. However, its role in mature adipocytes under physiological and pathological conditions remains unclear. Here, we report a major function of BECN1 in the regulation of basal autophagy in mature adipocytes. We also show that berberine, a natural plant alkaloid, inhibits basal autophagy in adipocytes and adipose tissue of mice fed a high-fat diet via downregulation of BECN1 expression. We further demonstrate that berberine has a pronounced effect on the stability of Becn 1 mRNA through the Mir30 family. These findings explore the potential of BECN1 as a key molecule and a drug target for regulating autophagy in mature adipocytes. Twit Text FOAVip Berberine attenuates autophagy in adipocytes by targeting BECN1 ????Autophagy http://www.kidney.de/pget.php?&tw=1&pmid=25126729 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=25126729 #FOAvip English Wikipedia <ref>{{Cite pmid|25126729 }}</ref> Berberine attenuates autophagy in adipocytes by targeting BECN1 #MMPMID25126729 Deng Y ; Xu J ; Zhang X ; Yang J ; Zhang D ; Huang J ; Lv P ; Shen W ; Yang Y Autophagy 2014[Oct]; 10 (10 ): 1776-86 PMID25126729 show ga The lysosomal degradation pathway, autophagy, is essential for the maintenance of cellular homeostasis. Recently, autophagy has been demonstrated to be required in the process of adipocyte conversion. However, its role in mature adipocytes under physiological and pathological conditions remains unclear. Here, we report a major function of BECN1 in the regulation of basal autophagy in mature adipocytes. We also show that berberine, a natural plant alkaloid, inhibits basal autophagy in adipocytes and adipose tissue of mice fed a high-fat diet via downregulation of BECN1 expression. We further demonstrate that berberine has a pronounced effect on the stability of Becn 1 mRNA through the Mir30 family. These findings explore the potential of BECN1 as a key molecule and a drug target for regulating autophagy in mature adipocytes. |3T3-L1 Cells [MESH] |Adipocytes/*cytology/drug effects/*metabolism/ultrastructure [MESH] |Animals [MESH] |Apoptosis Regulatory Proteins/genetics/*metabolism [MESH] |Autophagy/*drug effects [MESH] |Beclin-1 [MESH] |Berberine/*pharmacology [MESH] |Diet, High-Fat [MESH] |Mice [MESH] |Mice, Inbred C57BL [MESH] |MicroRNAs/metabolism [MESH] |Models, Biological [MESH] |RNA Stability/drug effects [MESH] |RNA, Messenger/genetics/metabolism [MESH]Berberine attenuates autophagy in adipocytes by targeting BECN1 (epmc).pdf DeepDyve Pubget Overpricing