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Benzopyran derivatives from Melicope pteleifolia #MMPMID41389032
Cham PT; Vien LT; Ngoc NT; Hanh TTH; Cuong NT; Cuong NX; Nam NH
J Asian Nat Prod Res 2025[Dec]; ? (?): 1-9 PMID41389032show ga
Phytochemical investigation of M. pteleifolia branches and leaves led to the isolation of seven benzopyran derivatives, including five new ones named melicopols A - E (2 - 6). The chemical structures were confirmed by extensive analysis of the 1D, 2D NMR, CD, and HR-QTOF mass spectra. The absolute configuration 1'S of leptol A (1) was firstly confirmed by experimental and calculated ECD data. Their cytotoxic activity on three human cancer cell lines HepG2 (hepatoma), SK-LU-1 (lung), and MCF7 (breast) was also evaluated using SRB assay.