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2017 ; 8
(ä): 437
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Behavioral Changes in Patients with Multiple Sclerosis
#MMPMID28894432
Heldner MR
; Kaufmann-Ezra S
; Gutbrod K
; Bernasconi C
; Bigi S
; Blatter V
; Mattle HP
; Müri RM
; Verma RK
; Kamm CP
Front Neurol
2017[]; 8
(ä): 437
PMID28894432
show ga
BACKGROUND: Behavioral changes are common in patients with multiple sclerosis
(MS), however not as readily recognized as cognitive impairments. OBJECTIVE: The
aim of this study was to analyze behavioral changes and its relation to disease
characteristics, disability, and cognitive impairments in patients with MS.
METHOD: This is a single-center cross-sectional study. A detailed
neuropsychological examination, including the Frontal Systems Behavior Scale
(FrSBe), the Beck depression inventory (BDI), and the Wuerzburg Fatigue Inventory
for Multiple Sclerosis (WEIMuS) test, was performed. FrSBe results were
correlated with disease characteristics, disability, and cognitive assessments.
RESULTS: 66 patients were enrolled (mean age: 43.4?years; disease duration:
9.3?years; Expanded Disability Status Scale: 3.0). Up to one third of patients
showed behavioral changes in at least one domain or the total score of the FrSBe.
Patients were mildly affected with regard to cognitive functioning. Consistent
correlation was found between behavioral changes and fatigue (WEIMuS) and
depressive symptoms (BDI), but not with disease characteristics, disability, or
cognitive functions. There was an increase of behavioral changes on all FrSBe
scales in the current status compared to the retrospectively rated status before
disease onset. Self- and family ratings with regard to current behavioral changes
were similar. CONCLUSION: Behavioral changes are common in otherwise mildly
affected MS patients with up to one third being affected. In this patient cohort,
behavioral changes occur largely independent of disease characteristics, physical
disability, and cognitive functioning but correlate with both fatigue and
depressive symptoms. Therefore, they should be tested specifically.