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2011 ; 40
(7
): 3391-404
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Beating cancer in multiple ways using nanogold
#MMPMID21629885
Dreaden EC
; Mackey MA
; Huang X
; Kang B
; El-Sayed MA
Chem Soc Rev
2011[Jul]; 40
(7
): 3391-404
PMID21629885
show ga
Gold nanoparticles possess a unique combination of properties which allow them to
act as highly multifunctional anti-cancer agents (X. H. Huang, P. K. Jain, I. H.
El-Sayed and M. A. El-Sayed, Nanomedicine, 2007, 2, 681-693; P. Ghosh, G. Han, M.
De, C. K. Kim and V. M. Rotello, Adv. Drug Delivery Rev., 2008, 60, 1307-1315; S.
Lal, S. E. Clare and N. J. Halas, Acc. Chem. Res., 2008, 41, 1842-1851; D. A.
Giljohann, D. S. Seferos, W. L. Daniel, M. D. Massich, P. C. Patel and C. A.
Mirkin, Angew. Chem., Int. Ed., 2010, 49, 3280-3294). Not only can they be used
as targeted contrast agents for photothermal cancer therapy, they can serve as
scaffolds for increasingly potent cancer drug delivery, as transfection agents
for selective gene therapy, and as intrinsic antineoplastic agents. This tutorial
review will highlight some of the many forms and recent applications of these
gold nanoparticle conjugates by our lab and others, as well as their rational
design and physiologic interactions.