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2013 ; 123
(3
): 1013-5
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Bathing the brain
#MMPMID23434595
Strittmatter WJ
J Clin Invest
2013[Mar]; 123
(3
): 1013-5
PMID23434595
show ga
The brain and spinal cord are surrounded by cerebrospinal fluid, which provides a
mechanically stable environment for these delicate structures against the forces
of gravity and sudden acceleration and deceleration. Neurons and glia comprising
the parenchyma of the brain are enveloped in their microenvironment by
interstitial fluid. Interstitial fluid has long been considered to be unaffected
by the production and flow of cerebrospinal fluid outside the brain parenchyma.
However, two recent papers by Iliff et al. demonstrate that cerebrospinal fluid
enters the deep substance of the brain, mixes with the interstitial fluid
surrounding neurons and glia, and plays an important role in the exchange and
clearance of molecules in the interstitial space of the central nervous system.
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