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2020 ; 18
(8
): 461-471
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Bat-borne virus diversity, spillover and emergence
#MMPMID32528128
Letko M
; Seifert SN
; Olival KJ
; Plowright RK
; Munster VJ
Nat Rev Microbiol
2020[Aug]; 18
(8
): 461-471
PMID32528128
show ga
Most viral pathogens in humans have animal origins and arose through
cross-species transmission. Over the past 50 years, several viruses, including
Ebola virus, Marburg virus, Nipah virus, Hendra virus, severe acute respiratory
syndrome coronavirus (SARS-CoV), Middle East respiratory coronavirus (MERS-CoV)
and SARS-CoV-2, have been linked back to various bat species. Despite decades of
research into bats and the pathogens they carry, the fields of bat virus ecology
and molecular biology are still nascent, with many questions largely unexplored,
thus hindering our ability to anticipate and prepare for the next viral outbreak.
In this Review, we discuss the latest advancements and understanding of bat-borne
viruses, reflecting on current knowledge gaps and outlining the potential routes
for future research as well as for outbreak response and prevention efforts.
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